Peter Thomas Roth Peptide Skinjection Amplified Refillable Wrinkle-Fix Serum — 19% Peptide Complex, Firms & Smooths

Peter Thomas Roth Peptide Skinjection™ Amplified Wrinkle-Fix Serum is a refillable, peptide-rich topical treatment designed to visibly soften expression lines and support firmer-looking skin without needles.

This lightweight, dual-purpose serum blends a concentrated peptide complex with targeted delivery to help reduce the appearance of expression lines and slow the look of future wrinkles. Formulated to be used alone as a needle-free option or alongside in-office injectable treatments, the serum brings together multiple clinically studied peptide actives and a refillable design to reduce waste while making advanced peptide technology accessible at home.

How does this serum work to reduce expression lines?

The formula combines several peptide solutions that act on different skin-signaling pathways related to muscle movement and collagen behavior. These peptides help temporarily relax the appearance of lines and encourage matrix-supporting activity for a smoother surface over time.

• 19% total peptide complex concentration for layered activity
• Includes 2% Matrixyl Morphomics and 2% Matrixyl Synthe’6 to support matrix proteins
• 5% Argireline Amplified targets expression-related movement
• 10% Argirelox™ helps extend aesthetic results between injectable sessions (study-based observation)

Can I use this serum with cosmetic injectables?

The product is formulated to complement in-office neurotoxin treatments as well as serve as a non-invasive alternative. In a supporting in vivo study, a peptide solution similar in profile helped prolong visible benefit after a single neurotoxin procedure when applied regularly.

• Designed for use both before and after injectable sessions
• Topical peptides may support longer-lasting surface improvements
• Follow your practitioner’s timeline for post-procedure skincare

How should I layer this serum in my routine?

Apply the serum to clean, dry skin morning and evening for best results; it absorbs quickly and pairs well with most moisturizers and sunscreens. Because of the high peptide levels, allow the serum a moment to penetrate before following with heavier creams or oils.

• Use twice daily on cleansed skin for consistent results
• Apply moisturizer and SPF during daytime after serum
• Reinsert refill cartridges into the eco-minded dispenser to reduce packaging waste

What results can I expect and when?

Individual responses vary, but many people notice smoother-looking expression lines with continued use over weeks to months. The formula’s blend of fast-acting peptides and peptides that support matrix-building offers both immediate visual refinement and longer-term support for skin firmness.

• Visible softening of expression lines with regular application
• Supportive effects on skin firmness and texture over time
• Refillable format maintains product potency and reduces waste

Who is this for: This serum is intended for adults looking to address expression lines and early signs of firmness loss without injections, or for those who want a topical protocol to complement professional aesthetic treatments. It suits all skin types and is particularly appealing if you want a high-concentration peptide approach in a refillable dispenser to limit single-use packaging.

Ingredients

Water/Aqua/Eau, Dimethicone, Squalane, Butylene Glycol, Glycerin, Saccharomyces Lysate, Polysilicone-11, Acetyl Hexapeptide-8, Pentapeptide-18, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Palmitoyl Tripeptide-38, Collagen, Sodium Hyaluronate, Tocopherol, Phytosterols, Hydrogenated Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Citric Acid, Caprylic/Capric Triglyceride, Polyglyceryl-10 Myristate, Pentylene Glycol, Caprylyl Glycol, Sodium Benzoate, Sodium Phytate, Sodium Hydroxide, Potassium Sorbate, Ethylhexyl Palmitate, Hydroxypropyl Cyclodextrin Trihydroxystearin, Lauroyl Lysine, Glucomannan, Ethylhexylglycerin, Ammonium Acryloyldimethyltaurate/VP Copolymercarbomer, Glyceryl Stearate, Stearyl Alcohol, Behenyl Alcohol, Mica, Phenoxyethanol.