Perricone MD High Potency Retinol Overnight Moisturizer — 2 fl oz Triple Retinol Night Cream for Hydration & Firming

Perricone MD High Potency Retinol Recovery Overnight Moisturizer is a rich night cream combining three forms of retinol with hydrating lipids to visibly smooth, firm, and replenish skin while you sleep.

This concentrated overnight treatment is formulated to support skin renewal and intense hydration. It blends encapsulated retinol, a retinol ester and a phyto-retinol along with firming DMAE and a vegetable triglyceride complex to help skin appear smoother, plumper and more resilient by morning. The texture is nourishing without feeling greasy, designed to reinforce the skin’s moisture barrier and reduce the look of fine lines over repeated use.

How does the triple retinol blend work while I sleep?

The formula uses three complementary retinol forms to encourage gentle surface renewal and improve visible texture. Encapsulation aids delivery, the ester form offers stability with gradual action, and the plant-derived retinoid provides additional supportive activity. Together they aim to accelerate exfoliation and promote a more refined skin appearance without excessive irritation for many users.

• Encapsulated retinol for controlled release and targeted delivery
• Retinol ester for sustained, stable retinoid activity
• Phyto-retinol (plant-derived) to support visible renewal

Will this moisturizer help hydrate and strengthen my skin barrier?

Yes—this night cream includes a vegetable triglyceride complex made from oils like jojoba, soybean and olive to deeply condition and help protect the barrier. These lipids lock in moisture and smooth skin surface texture, while phytosterols within the complex can contribute to improved elasticity over time. The result is skin that looks and feels plumper and more supple.

• Jojoba, soybean and olive-derived lipids for sustained hydration
• Phytosterols to support elasticity and surface softness
• Barrier-protecting nutrients that reduce moisture loss overnight

How does DMAE contribute to visible firmness?

DMAE is included for its quick absorption and temporary plumping effect to help skin look firmer. Applied topically, it can help tighten the skin’s surface appearance and enhance overall definition. Over continued use, DMAE works alongside the retinol system to support the look of lifting and refined contours.

• Rapidly absorbed DMAE to visibly tighten and lift
• Plumping action that supports smoother-looking lines
• Pairs with retinoids for complementary firming benefits

How should I add this to my nightly routine to minimize irritation?

Start by applying every other night or a few times weekly if you are new to retinoids, then increase frequency as tolerated. Use a pea-sized amount and smooth it over clean, dry skin after cleansing and any water-based serums; follow with sunscreen the next morning. If irritation appears, reduce application frequency and ensure supportive hydration with gentle cleansers and moisturizers.

• Begin slowly—every other night, then increase as tolerated
• Apply a small amount to clean, dry skin in the evening only
• Use daily sunscreen in the morning when using retinoids

Who is this for: Perricone MD High Potency Retinol Recovery Overnight Moisturizer is suited for adults who want a targeted night treatment to help refine texture, smooth fine lines and restore hydration. It’s especially appropriate for individuals familiar with retinoids seeking a potent, multi-form retinol system paired with nourishing lipids and DMAE. Avoid use if you have severe sensitivity to retinol; consult a dermatologist for personalized guidance.

Ingredients

Water/Aqua/Eau, Caprylic/Capric Triglyceride, C12-15 Alkyl Benzoate, Propanediol, Shea Butter Ethyl Esters, Dicaprylyl Carbonate, Cetearyl Alcohol, Dimethicone, Squalane, Behenyl Alcohol, Hydrogenated Vegetable Glycerides, Isoamyl Laurate, Aleurites Moluccanus Seed Oil, Glyceryl Stearate, PEG-100 Stearate, Hydrogenated Vegetable Oil, Hydrogenated Soybean Oil, Ceteareth-20, Glycerin, Phenoxyethanol, Polysilicone-11, Sodium Stearoyl Glutamate, Hydrogenated Olive Oil, Citric Acid, Dimethyl MEA, Petrolatum, Hydrogenated Jojoba Oil, Ethylhexylglycerin, Retinol, Retinyl Linoleate, Xanthan Gum, Polysorbate 20, Fragrance (Parfum), Tetrasodium Glutamate Diacetate, Helianthus Annuus (Sunflower) Seed Oil, Glycine Soja (Soybean) Lipids, Maltodextrin, Pentylene Glycol, Cetyl Palmitate, Laureth-23, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Nephelium Lappaceum Leaf Extract, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Ceramide NP, Sodium Hydroxide, Trideceth-6 Phosphate, Magnesium Aspartate, Zinc Gluconate, Rosmarinus Officinalis (Rosemary) Leaf Extract, Magnesium Sulfate, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Phytosterols, Tocopherol, Copper Gluconate, Citronellol, Geraniol, Hydroxycitronellal, Eugenol.