Neutrogena Stubborn Acne Spot Drying Lotion — 1 fl oz | 10% Sulfur, 4% Niacinamide, Fragrance-Free Overnight Treatment

Neutrogena Stubborn Acne Spot Drying Lotion is an overnight spot treatment that uses 10% sulfur and 4% niacinamide to visibly reduce the size and redness of stubborn pimples.

This compact, fragrance-free lotion is formulated for acne-prone skin and designed to be applied directly to individual blemishes. With dermatologist-recommended ingredients and a paraben-, phthalate-, dye-, and oil-free base, it targets pimples while helping address post-acne marks. Use at night for fast-acting results and pair with daytime patches if you want round‑the‑clock care.

How quickly will I see pimples start to shrink?

Many users notice visible improvement within one use, especially reduced swelling and redness by morning. The high 10% sulfur concentration helps draw out buildup while calming ingredients work on inflammation.

• Contains 10% sulfur — the highest OTC level — to penetrate clogged pores.
• Clinically shown to produce fast-acting visible results for individual pimples.
• Apply at night and check for reduced size and redness the next day.

What does niacinamide do in this formula?

Niacinamide at 4% helps even out skin tone and supports the fade of dark spots that follow breakouts, without adding oils or heavy fragrances. It complements sulfur’s drying action by reducing the appearance of pigmentation left behind.

• 4% niacinamide targets post-acne discoloration and evens skin tone.
• Non-comedogenic and oil-free, so it won’t clog pores.
• Works alongside sulfur to address both active blemishes and marks.

How do I use the spot drying lotion safely and effectively?

Cleanse the skin first, then apply a thin layer to the affected area using a clean cotton swab; do not rub it in. Leave it on overnight so the lotion can dry and do its work, then rinse in the morning with warm water.

• Use a clean cotton swab for targeted application — avoid rubbing.
• Apply in the PM and remove in the AM to minimize irritation and staining.
• Safe to pair with Stubborn Acne Blemish patches for all-day treatment.

Is this suitable for sensitive or acne-prone skin?

The formula is fragrance-, paraben-, phthalate-, dye-, and oil-free, which reduces common irritants and makes it better tolerated by many sensitive or acne-prone skin types. Still, start with a small spot test if you have very reactive skin, and avoid combining with other strong actives at the same application time.

• Fragrance-free and free of common irritants to lower sensitivity risk.
• Contains calming zinc oxide and calamine to soothe breakout discomfort.
• Recommended to patch-test on a small area before broad use.

Who is this for: Neutrogena Stubborn Acne Spot Drying Lotion is intended for people who want a targeted, overnight treatment for individual pimples — especially those seeking fast visible results without fragrances or added oils. It’s well suited to acne-prone skin that needs a focused solution for stubborn spots and accompanying post‑acne marks, and for anyone who prefers a simple, dermatologist-backed product in their spot-treatment routine.