Lancôme Absolue Longevity MD Reset Serum for Mature Skin — Mitopure & Niacinamide, Firms Texture & Reduces Fine Lines

Lancôme Absolue Longevity MD Reset Serum is a targeted anti-aging serum that helps reset visible signs of biological skin aging using Mitopure, Senevisium and niacinamide.

This lightweight serum is designed for mature skin concerned with firmness, texture and the appearance of fine lines. Formulated from Lancôme’s longevity research, it combines a postbiotic ingredient (Mitopure®) with skin-supporting actives to encourage visible renewal and bolster skin tonicity after application and over time. Results reported in clinical and instrumental testing include improved skin tone, accelerated surface cell renewal, and measurable increases in firmness and elasticity.

How quickly does this serum affect skin tone and firmness?

In an instrumental study, skin tonicity increased within hours of application, indicating an immediate feel of firmness. Continued use supports the skin’s structural appearance and may enhance elasticity as part of a broader routine.

• Instrumental test: +41% skin tonicity at 4 hours post-application
• Daily application supports a firmer, more lifted look over time
• Suitable as part of morning or evening skincare routines

Will it help with texture and visible surface renewal?

Yes — clinical data show increased surface cell renewal, helping to replace dull cells and refine skin texture. This resurfacing effect contributes to a smoother, more even complexion with regular use.

• Clinical exfoliation study: +20% more renewed surface cells over three weeks vs. untreated skin
• Niacinamide (Vitamin B3) supports moisture retention and texture smoothing
• Use alongside gentle exfoliation and sunscreen for best cosmetic results

What key actives are inside and what do they do?

The formula centers on Mitopure®, a postbiotic associated with longevity research, plus Senevisium and vitamin B3 to support visible skin resilience. Together these ingredients aim to promote a healthier-looking surface and help skin appear less affected by visible aging signs.

• Mitopure®: a longevity-focused postbiotic to address visible biological aging signs
• Senevisium: supports the appearance of youthful skin mechanics and vitality
• Niacinamide: optimizes moisture retention and smooths skin texture

How should I add this serum to my routine and what results can I expect?

Apply the serum to cleansed skin before moisturizer, morning and/or evening, depending on your routine. You may notice improved tone in hours and gradual textural refinement and firmer appearance with ongoing use; combine with sunscreen during the day for overall skin health.

• Use after cleansing and before creams or oils
• Compatible with other anti-aging products in a layered regimen
• Visible improvements reported in clinical and instrumental evaluations

Who this is for: Lancôme Absolue Longevity MD Reset Serum is aimed at mature skin types seeking cosmetic solutions for visible signs of aging—those who want to improve firmness, refine texture and support skin tone using a formula grounded in longevity science. It is suitable for anyone looking to add a clinically-backed serum to an anti-aging skincare routine; avoid if you have sensitivities to listed ingredients and consult with a dermatologist for personalized advice.

Ingredients

AQUA / WATER / EAU • GLYCERIN • RHAMNOSE • NIACINAMIDE • ALCOHOL DENAT. • CETYL ALCOHOL • BUTYROSPERMUM PARKII BUTTER / SHEA BUTTER • DIMETHICONE • PEG/PPG/POLYBUTYLENE GLYCOL-8/5/3 GLYCERIN • DICAPRYLYL CARBONATE • STEARYL ALCOHOL • UROLITHIN A • HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID • OCTYLDODECANOL • ROSA DAMASCENA FLOWER WATER • GINKGO BILOBA LEAF EXTRACT • CARBOMER • SODIUM HYALURONATE • SODIUM HYDROXIDE • SODIUM LACTATE • SODIUM METHYL STEAROYL TAURATE • ARGININE • SILICA • CELLULOSE • PALMITOYL TETRAPEPTIDE-7 • PALMITOYL TRIPEPTIDE-1 • ADENOSINE • PROPANEDIOL • PROPYLENE GLYCOL • HYDROXYPROPYL TETRAHYDROPYRANTRIOL • CITRIC ACID • TAURINE • TRISODIUM ETHYLENEDIAMINE DISUCCINATE • XANTHAN GUM • PENTYLENE GLYCOL • POLYSORBATE 20 • BUTYLENE GLYCOL • TOCOPHEROL • SALICYLIC ACID • PHENOXYETHANOL • CHLORPHENESIN • CARAMEL • PARFUM / FRAGRANCE