Cetaphil Deep Hydration 48-Hour Activation Serum, Fragrance-Free 1 fl oz — Lightweight Hydration for Sensitive Skin

Cetaphil Deep Hydration 48 Hour Activation Serum is a lightweight, fragrance-free facial serum that delivers extended hydration and soothes sensitive, dry skin for up to 48 hours.

This serum is formulated to rapidly absorb and strengthen skin’s moisture balance without leaving a greasy film. It combines a targeted hydration complex with hyaluronic acid, vitamin B5, vitamin E and sunflower seed oil to help replenish and calm skin that tends toward dryness or sensitivity. The texture is thin enough for layering under day or night creams and gentle enough for skin-prone irritation.

How quickly will it hydrate my skin and how long does it last?

The formula is designed for fast absorption so you feel dampness diminish almost immediately while hydration is retained over time. Clinical testing shows prolonged moisture support that can last up to 48 hours after application, helping skin look and feel less tight.

• Lightweight serum absorbs rapidly into skin layers
• Hydrosensitiv Complex targets dynamic hydration
• Supports up to 48 hours of improved moisture balance

Will this serum work for sensitive or acne-prone skin?

It was developed for sensitive skin and is clinically tested to minimize irritation. The formula is non-comedogenic and fragrance-free, so it won’t clog pores and is less likely to cause reactions for reactive skin types.

• Fragrance-free and clinically tested on sensitive skin
• Non-comedogenic formulation that avoids pore blockage
• Soothing ingredients reduce the feeling of tightness and discomfort

What active ingredients help improve skin hydration and texture?

Hyaluronic acid attracts and locks in moisture, while vitamin B5 supports skin’s natural repair processes. Sunflower seed oil provides lightweight lipids to help restore barrier function, and vitamin E brings antioxidant support to help skin appear healthier.

• Hyaluronic acid for moisture retention and plumping effect
• Vitamin B5 to support comfort and surface recovery
• Sunflower seed oil and vitamin E to replenish lipids and antioxidants

How should I use the serum in my routine?

Apply a few drops to clean, dry skin morning and/or night before moisturizer. It layers easily under creams or sunscreen and can also be used alone when you want a lighter finish.

• Use after cleansing and toning, before heavier creams
• Allow a moment to absorb, then follow with moisturizer or SPF
• Can be used daily for ongoing hydration support

Who this product is for: Cetaphil Deep Hydration 48 Hour Activation Serum suits people with dry, dehydrated or sensitive skin who want a gentle, effective hydration boost. It's ideal for anyone seeking a fragrance-free, non-comedogenic serum to layer under their existing moisturizer or to use on its own for lightweight, long-lasting moisture support. If you need a dermatologist-recommended option that focuses on restoring skin comfort and moisture without heavy oils or perfumes, this serum is a practical addition to your skincare routine.

Ingredients

Water, Glycerin, Sorbitol, Coco-Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Helianthus Annuus (Sunflower) Seed Oil, Octyldodecanol, Hexyldecanol, Hexyldecyl Laurate, Distarch Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Butyrospermum Parkii(Shea)Oil, Citric Acid, Dicaprylyl Carbonate, Disodium Cocoyl Glutamate, Globulariaalypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Panthenol (Vitamin B5), Pantolactone, Phenoxyethanol, Propylene Glycol, Sodium Benzoate, Sodium Hydroxide, Sodium Polyacrylate, Tocopherol (Vitamin E), Tocopheryl Acetate (Vitamin E Acetate), Xylitol, Xylitylglucoside